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Courses in Biomedical Engineering (BIM)

Lower Division

1. Introduction to Biomedical Engineering (2)

Lecture—1 hour; laboratory—3 hours. Pass One open to freshmen. Introduction to the field of biomedical engineering with emphasis on design, careers, and specializations, including (1) medical devices (2) cellular & tissue engineering, (3) biomechanics, (4) systems & synthetic biology, and (5) biomedical imaging. GE credit: SciEng | SE.—F. (F.) Choi

20. Fundamentals of Bioengineering (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: C- or better in Chemistry 2B and Mathematics 21D; Physics 9B. Basic principles of mass, energy and momentum conservation equations applied to solve problems in the biological and medical sciences. Only two units of credit to students who have previously taken Chemical Engineering 51, Engineering 105. GE credit: SciEng | QL, SE, VL.—S. (S.) Choi

89A. Topics in Biomedical Engineering (1-5)

Prerequisite: consent of instructor. Restricted to lower division students. Topics in Biomedical Engineering. (A) Cellular and Molecular Engineering. May be repeated for credit when topic differs. GE credit: SciEng | SE.

89B. Topics in Biomedical Engineering (1-5)

Prerequisite: consent of instructor. Restricted to lower division students. Topics in Biomedical Engineering. (B) Biomedical Imaging. May be repeated for credit when topic differs. GE credit: SciEng | SE.

89C. Topics in Biomedical Engineering (1-5)

Prerequisite: consent of instructor. Restricted to lower division students. Topics in Biomedical Engineering. (C) Biomedical Engineering. May be repeated for credit when topic differs. GE credit: SciEng | SE.

99. Special Study for Undergraduates (1-5)

(P/NP grading only.) GE credit: SE.

Upper Division

102. Quantitative Cell Biology (4)

Lecture/discussion—4 hours. Prerequisite: Biological Sciences 2A; Chemistry 8B. Open to College of Engineering students only. Fundamental cell biology for bioengineers. Emphasis on physical concepts underlying cellular processes including protein trafficking, cell motility, cell division and cell adhesion. Current topics including cell biology of cancer and stem cells will be discussed. Only two units of credit for students who have completed Biological Sciences 104 or Molecular and Cellular Biology 143. GE credit: SciEng | QL, SE, VL.—F. (F.) Yamada

105. Probability and Statistics for Biomedical Engineers (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: C- or better in Mathematics 21D; Engineering 6 (may be concurrent). Concepts of probability, random variables and processes, and statistical analysis with applications to engineering problems in biomedical sciences. Includes discrete and continuous random variables, probability distributions and models, hypothesis testing, statistical inference and Matlab applications. Emphasis on BME applications. GE credit: SciEng | QL, SE, VL.—F. (F.) Rocke

106. Biotransport Phenomena (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: C- or better in course 20; course 116 or Neurobiology, Physiology, and Behavior 101; Physics 9B; Mathematics 22B. Open to Biomedical Engineering majors only. Principles of momentum and mass transfer with applications to biomedical systems; emphasis on basic fluid transport related to blood flow, mass transfer across cell membranes, and the design and analysis of artificial human organs. GE credit: SciEng | QL, SE, SL, VL.—W. (W.) Tan

107. Mathematical Methods for Biological Systems (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: C- or better in Engineering 6; course 20; Mathematics 22B. Restricted to Biomedical Engineering majors only. Mathematical and computational modeling to solve biomedical problems. Topics include stochastic processes and Monte Carlo simulations, and partial differential equations. Introduced to numerical techniques in MATLAB. Offered irregularly. GE credit: SciEng | QL, SE, VL.

108. Biomedical Signals and Control (4)

Lecture—4 hours. Prerequisite: Engineering 6, 17; grade of C- or better in Mathematics 22B. Restricted to Biomedical Engineering majors only. Systems and control theory applied to biomedical engineering problems. Time-domain and frequency-domain analyses of signals and systems, convolution, Laplace and Fourier transforms, transfer function, dynamic behavior of first and second order processes, and design of control systems for biomedical applications. No credit for students who have taken Electrical and Computer Engineering 150A; two units of credit for students who have taken Mechanical Engineering 171. GE credit: SciEng | QL, SE.—S. (S.) Qi

109. Biomaterials (4)

Lecture—4 hours. Prerequisite: course 106; Biological Sciences 2A; Chemistry 2C. Restricted to upper-division Engineering majors. Introduce important concepts for design, selection and application of biomaterials. Given the interdisciplinary nature of the subject, principles of polymer science, surface science, materials science and biology will be integrated into the course. GE credit: SciEng | SE, SL, VL.—S. (S.) Revzin

110A. Biomedical Engineering Senior Design Experience (3)

Lecture/discussion—1 hour; project—6 hours. Prerequisite: course 110L (may be concurrent); course 111 (may be concurrent); consent of instructor. Restricted to senior Biomedical Engineering majors (or by consent of instructor). Application of bioengineering theory and experimental analysis to a design project culminating in the design of a unique solution to a problem. Design may be geared towards current applications in biotechnology or medical technology. Continues in course 110B. (Deferred grading only, pending completion of sequence.) GE credit: SciEng | SE, OL, SL, VL.—W. (W.) Passerini

110B. Biomedical Engineering Senior Design Experience (3)

Lecture/discussion—1 hour; project—6 hours. Prerequisite: course 110A. Application of bioengineering theory and experimental analysis to a design project culminating in the design of a unique solution to a problem. Design may be geared towards current applications in biotechnology or medical technology. (Deferred grading only, pending completion of sequence.) GE credit: SciEng |  OL, SE, SL, VL.—S. (S.)  Passerini

110L. Biomedical Engineering Senior Design Lab (2)

Laboratory—3 hours; laboratory/discussion—2 hours. Prerequisite: courses 105, 108, 109. Restricted to Senior Biomedical Engineering majors. Manufacturing processes, safety, and computer-aided design techniques applied to the fabrication of biomedical devices. Application of bioengineering principles and design theory to a project culminating in completion of a functional prototype that solves a biomedical problem. Continues in 110AB. (Deferred grading only, pending completion of sequence.) GE credit: SciEng | SE.—F, W. (F, W.) Passerini

111. Biomedical Instrumentation Laboratory (6)

Lecture—4 hours; discussion/laboratory—4 hours. Prerequisite: courses 105, and 108; Engineering 100 or Electrical Engineering 100; course 116 or Neurobiology, Physiology, & Behavior 101. Open to Biomedical Engineering majors only. Basic biomedical signals and sensors. Topics include analog and digital records using electronic, hydrodynamic, and optical sensors, and measurements made at cellular, tissue and whole organism level. GE credit: SciEng | SE.—F, W. (F, W.) Marcu, Pan

116. Physiology for Biomedical Engineers (5)

Lecture—2 hours; discussion—3 hours. Prerequisite: C- or better in Biological Sciences 2A; Physics 9C; Mathematics 22B recommended. Basic human physiology for the nervous, musculoskeletal, cardiovascular, respiratory, gastrointestinal, renal, and endocrine systems. Emphasis on small group design projects and presentations in interdisciplinary topics relating biomedical engineering to medical diagnostic and therapeutic applications. GE credit: SciEng | OL, SE, SL, VL, WE.—F. (F.) Silva

117. Analysis of Molecular and Cellular Networks (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: grade of C- or better in Biological Sciences 2A and Mathematics 22A. Restricted to upper division standing. Network themes in biology, emphasizing metabolic, genetic, and developmental networks. Mathematical and computational methods for analysis of such networks. Elucidation of design principles in natural networks. Engineering and ethical issues in the design of synthetic networks. Offered alternate years. GE credit: SciEng |  QL, SE, SL, VL.Savageau

118. Microelectromechanical Systems (4)

Lecture—2 hours; laboratory—3 hours; discussion—1 hour. Prerequisite: Chemistry 2A; Engineering 17. Restricted to upper division standing in College of Engineering. One restricted to upper division standing in Biomedical Engineering. Introduction to the theory and practice of micro-electromechanical systems (MEMS), including fundamentals of micro-nanofabrication, microscale sensing and actuation, self assembly, microfluidics and lab-on-a-chip. Weekly hands-on laboratory sections are emphasized on implementation and utilization of MEMS technologies. GE credit: SciEng | SE.—S. (S.) Pan

126. Tissue Mechanics (3)

Lecture—2 hours; laboratory/discussion—3 hours. Prerequisite: Exercise Science 103 and/or Engineering 45 and/or consent of instructor. Structural and mechanical properties of biological tissues, including bone, cartilage, ligaments, tendons, nerves, and skeletal muscle. (Same course as Exercise Biology 126.) GE credit: SciEng | QL, SE, SL, WE.

140. Protein Engineering (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: Biological Sciences 2A. Introduction to protein structure and function. Modern methods for designing, producing, and characterizing novel proteins and peptides. Design strategies, computer modeling, heterologous expression, in vitro mutagenesis. Protein crystallography, spectroscopic and calorimetric methods for characterization, and other techniques. Offered in alternate years. GE credit: SciEng | QL, SE, SL, VL.—(S.) Facciotti

141. Cell and Tissue Mechanics (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: Physics 9B; Engineering 6; Engineering 35. Mechanical properties that govern blood flow in the microcirculation. Concepts in blood rheology and cell and tissue viscoelasticity, biophysical aspects of cell migration, adhesion, and motility. GE credit: SciEng | QL, SE, VL.—W. (W.) Simon

142. Principles and Practices of Biomedical Imaging (4)

Lecture—4 hour. Prerequisite: Mathematics 22B, course 108 (may be taken concurrently). Basic physics, engineering principles, and applications of biomedical imaging techniques including x-ray imaging, computed tomography, magnetic resonance imaging, ultrasound and nuclear imaging. GE credit: SciEng | SE.—S. (S.) Cherry

143. Biomolecular Systems Engineering: Synthetic Biology (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: Biological Sciences 2A; Mathematics 16C or Mathematics 17C or Mathematics 21C. Includes analysis, design, construction and characterization of molecular systems. Process and biological parts standardization, computer aided design, gene synthesis, directed evolution, protein engineering, issues of human practice, biological safety, security, innovation, and ethics are covered. Offered in alternate years. GE credit: SciEng | SE.—S. Facciotti

151. Mechanics of DNA (3)

Lecture—3 hours. Prerequisite: Biological Sciences 2A and Mathematics 22B. Structural, mechanical and dynamic properties of DNA. Topics include DNA structures and their mechanical properties, in vivo topological constraints on DNA, mechanical and thermodynamic equilibria, DNA dynamics, and their roles in normal and pathological biological processes. GE credit: SciEng | OL, QL, SE.—Benham

152. Molecular Control of Biosystems (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: Biological Sciences 2A, Physics 9B and Mathematics 22B. Fundamentals of molecular biomedicine covering state-of-the-art methods for quantitative understanding of gene regulation and signal transduction networks at different levels of organization in health and disease. Topics include classic genetic systems, synthetic circuits, networks disrupted in disease and cancer. GE credit: SciEng | OL, SE.—S. (S.) Saiz

161A. Biomolecular Engineering (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: Biological Sciences 2A; Chemistry 8B. Restricted to upper division standing. Introduction to the basic concepts and techniques of biomolecular engineering such as recombinant DNA technology, protein engineering, and molecular diagnostics. Three units of credit for students who have taken course 161S. Offered in alternate years. GE credit: SciEng | QL, SE. —(F.) Tan

161L. Biomolecular Engineering Laboratory (3)

Laboratory—4.5 hours; lecture/discussion—1.5 hours. Prerequisite: course 161A or Biological Sciences 101. Introduction to the basic techniques in biomolecular engineering. Lectures, laboratory, and discussion sessions will cover basic techniques in DNA cloning, bacterial cell culture, gene regulation, protein expression, and data analysis. Offered irregularly. GE credit: SciEng |QL, SE, SL.

161S. Biomolecular Engineering: Brief Course (1)

Lecture—1 hour. Prerequisite: Biological Sciences 2A; Chemistry 8B; course 161L (may be taken concurrently). Basic concepts and techniques in biomolecular analysis, recombinant DNA technology, and protein purification and analysis. Not open for credit to students who have taken course 161A. Offered irregularly. GE credit: SciEng | QL, SE.

162. Introduction to the Biophysics of Molecules and Cells (4)

Lecture—4 hours. Prerequisite: C- or better in Mathematics 22B and Physics 9C. Introduction to fundamental physical mechanisms governing structure and function of bio-macromolecules. Emphasis on a quantitative understanding of the nano- to microscale biomechanics of interactions between and within individual molecules, as well as of their assemblies, in particular membranes. GE credit: SciEng | QL, SE, SL.—F. (F.) Heinrich

163. Bioelectricity, Biomechanics, and Signaling Systems (4)

Lecture—3 hours; lecture/discussion—1 hour. Prerequisite: C- or better in Mathematics 22B; course 116 or Neurobiology, Physiology, and Behavior 101. Fundamentals of bioelectricity in cells, the calcium signaling system, and mechanical force generation in muscle. Combination of lecture and projects to promote learning of important concepts in hands-on projects using neurons and muscle as microcosms. GE credit: SciEng | SE, QL.—S. (S.) Chen-Izu

167. Biomedical Fluid Mechanics (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: course 106 (may be taken concurrently) or Engineering 103. Basic biofluid mechanics, Navier Stokes equations of motion, circulation, respiration and specialized applications including miscellaneous topics such as boundary layer flow. Not open for credit to students who have completed Mechanical Engineering 167C. GE credit: SciEng | QL, SE.—S. (S.) Tan

173. Cell and Tissue Engineering (4)

Lecture/discussion—4 hours. Prerequisite: grade of C- or better in courses 106 and 109. Engineering principles to direct cell and tissue behavior and formation. Cell sourcing, controlled delivery of macromolecules, transport within and around biomaterials, bioreactor design, tissue design criteria and outcomes assessment. GE credit: SciEng | OL, SE, SL, WE.—F. (F.) Leach

189A. Topics in Biomedical Engineering; Cellular and Molecular Engineering (1-5)

Prerequisite: consent of instructor. Topics in Biomedical Engineering; Cellular and Molecular Engineering. May be repeated if topic differs. Offered irregularly. GE credit: SciEng | SE.

189B. Topics in Biomedical Engineering; Biomedical Imaging (1-5)

Prerequisite: consent of instructor. Topics in Biomedical Engineering; Biomedical Imaging. May be repeated if topic differs. Offered irregularly. GE credit: SciEng | SE.

189C. Topics in Biomedical Engineering; Biomedical Engineering (1-5)

Prerequisite: consent of instructor. Topics in Biomedical Engineering; Biomedical Engineering. May be repeated if topic differs. Offered irregularly. GE credit: SciEng | SE.

190A. Upper Division Seminar in Biomedical Engineering (1)

Seminar—1 hour. Restricted to upper division standing. In depth examination of research topics in a small group setting. Question and answer session with faculty members. May be repeated for credit. (P/NP grading only.) GE credit: SE.

192. Internship in Biomedical Engineering (1-12)

Internship—3-36 hours. Prerequisite: consent of instructor. Restricted to upper division majors. Supervised work experience in the Biomedical Engineering field. May be repeated for credit. (P/NP grading only.) GE credit: SE.—F, W, S, Su. (F, W, S, Su.)

198. Directed Group Study (1-5)

Prerequisite: consent of instructor. May be repeated up to three times for credit. (P/NP grading only.) GE credit: SE.—F, W, S. (F, W, S.)

199. Special Study for Advanced Undergraduates (1-5)

Prerequisite: consent of instructor. Special study for advanced undergraduates. (P/NP grading only.) GE credit: SE.

The Graduate Program in Biomedical Engineering

Doctoral and master's degrees in Biomedical Engi­neering are offered through the interdisciplinary Graduate Group in Biomedical Engineering. Please see http://www.bme.ucdavis.edu and Biomedical Engineering (A Graduate Group) of the catalog for a description of graduate education offerings, requirements, group faculty and research foci.

Graduate

202. Cell and Molecular Biology for Engineers (4)

Lecture/discussion—4 hours. Prerequisite: Biological Sciences 104 or Molecular and Cellular Biology 121. Preparation for research and critical review in the field of cell and molecular biology for biomedical or applied science engineers. Emphasis on biophysical and engineering concepts intrinsic to specific topics including receptor-ligand dynamics in cell signaling and function, cell motility, DNA replication and RNA processing, cellular energetics and protein sorting. Modern topics in bioinformatics and proteomics.—F. (F.) Yamada

204. Physiology for Bioengineers (5)

Lecture—4 hours. Prerequisite: Biological Sciences 1A or equivalent; graduate standing or consent of instructor. Basic human physiology of the nervous, muscular, cardiovascular, respiratory, and renal systems and their interactions; Emphasis on the physical and engineering principles governing these systems, including control and transport processes, fluid dynamics, and electrochemistry.—F. (F.) Benham

209. Scientific Integrity for Biomedical Engineers (2)

Lecture—1 hour; discussion—1 hour. Open to Biomedical Engineering majors only. Scientific integrity and ethics for biomedical engineers, with emphasis and discussion on mentoring, authorship and peer review, use of humans and animals in biomedical research, conflict of interest, intellectual property, genetic technology and scientific record keeping. (S/U grading only.)—S. (S.)  Simon

210. Introduction to Biomaterials (4)

Lecture—4 hours. Prerequisite: Engineering 45 or consent of instructor. Mechanical and atomic properties of metallic, ceramic, and polymeric implant materials of metallic, ceramic, and polymeric implant materials; corrosion, degradation, and failure of implants; inflammation, wound and fracture healing, blood coagulation; properties of bones, joints, and blood vessels; biocompatibility of orthopaedic and cardiovascular materials.—W. (W.) Fyhrie

211. Design of Polymeric Biomaterials and Biological Interfaces (4)

Lecture—4 hours. Prerequisite: Engineering 45 or consent of instructor. Open to upper division undergraduates or graduate students. Design, selection and application of polymeric biomaterials. Integration of the principles of polymer science, surface science, materials science and biology. Offered in alternate years.—(W.) Revzin

212. Biomedical Heat and Mass Transport Processes (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: Mechanical Engineering 165, Biological Systems Engineering 125, Chemical Engineering 153 or the equivalent. Application of principles of heat and mass transfer to biomedical systems related to heat exchange between the biomedical system and its environment, mass transfer across cell membranes and the design and analysis of artificial human organs. (Same course as Mechanical and Aeronautical Engineering 212.) Offered in alternate years.— W. Aldredge

213. Principles and Applications of Biological Sensors (4)

Lecture—4 hours. Prerequisite: Chemistry 2C. Biological sensors based on principles of electrochemical, optical and affinity detection. Methods for integration of sensing elements (e.g. enzymes) into biosensors and miniaturization of biosensors. Offered in alternate years.— F. Revzin

214. Blood Cell Biomechanics (4)

Lecture—4 hours. Prerequisite: Engineering 102. Mechanical properties that govern blood flow in the microcirculation and cell adhesion and motility. Constitutive equations of vasculature tissue and blood. Blood rheology and viscoelasticity. Red and white blood cell mechanics. Remodeling of blood vessels in disease and engineering of blood vessels and cells. Offered in alternate years.—(F.) Simon

215. Biomedical Fluid Mechanics and Transport Phenomena (4)

Lecture—3 hours; discussion—1 hour. Prerequisite: Engineering 103 or Chemical Engineering 150B or Civil and Environmental Engineering 141. Application of fluid mechanics and transport to biomedical systems. Flow in normal physiological function and pathological conditions. Topics include circulatory and respiratory flows, effect of flow on cellular processes, transport in the arterial wall and in tumors, and tissue engineering. (Same course as Mechanical and Aeronautical Engineering 215.) Offered irregularly.

216. Advanced Topics in Cellular Engineering (4)

Lecture—4 hours. Prerequisite: course 214 or consent of instructor. Advanced research strategies and technologies used in the study of immune function and inflammation. Static and dynamic measurements of stress, strain, and molecular scale forces in blood and vascular cells, as well as genetic approaches to the study of disease. Offered in alternate years.—F. Simon

217. Mechanobiology in Health and Disease (4)

Lecture/discussion—4 hours. Prerequisite: course 106 or equivalent (e.g. Engineering 103), Biological Sciences 101 or equivalent, Neurobiology, Physiology, and Behavior 101 or equivalent. Principles by which biomechanical forces affect cell and tissue function to impact human health and disease. Emphasis on cardiovascular system: structure and function, biofluid mechanics and mechanotransduction, disease mechanisms and research methods. Cartilage, bone and other systems; current topics discussed.— S. Passerini

218. Microsciences (4)

Lecture/discussion—4 hours. Introduction to the theory of physical and chemical principles at the microscale. Scale effects, surface tension, microfluidic mechanics, micromechanical properties, intermolecular interactions and micro tribology. (Same course as Electrical and Computer Engineering 244B.)—F. (F.) Pan

222. Cytoskeletal Mechanics (4)

Lecture/discussion—4 hours. Prerequisite: course 202. Current topics in cytoskeletal mechanics including physical properties of the cytoskeleton and motor proteins, molecular force sensor and generator, cytoskeletal regulation of cell motility and adhesion. Offered in alternate years.—(F.) Yamada

223. Multibody Dynamics (4)

Lecture—4 hours. Prerequisite: Engineering 102. Coupled rigid-body kinematics/dynamics; reference frames; vector differentiation; configuration and motion constraints; holonomicity; generalized speeds; partial velocities; mass; inertia tensor/theorems; angular momentum; generalized forces; comparing Newton/Euler, Lagrange's, Kane's methods; computer-aided equation derivation; orientation; Euler; Rodrigues parameters. (Same course as Mechanical and Aeronautical Engineering 223.)— W. (W.) Eke

225. Spatial Kinematics and Robotics (4)

Lecture—3 hours; laboratory—3 hours. Prerequisite: C Language and course 222. Spatial kinematics, screw theory, spatial mechanisms analysis and synthesis, robot kinematics and dynamics, robot workspace, path planning, robot programming, real-time architecture and software implementation. (Same course as Mechanical and Aeronautical Engineering 225.) Offered in alternate years.— W. Cheng

227. Research Techniques in Biomechanics (4)

Lecture—2 hours; laboratory—4 hours; term paper/
discussion—1 hour. Prerequisite: consent of instructor, Mathematics 22B; Exercise Science 115 recommended. Experimental techniques for biomechanical analysis of human movement are examined. Techniques evaluated include data acquisition and analysis by computer, force platform analysis, strength assessment, planar and three-dimensional videography, data reduction and smoothing, body segment parameter determination, electromyography, and biomechanical modeling. (Same course as Mechanical and Aeronautical Engineering 227/Exercise Science 227.)

228. Skeletal Muscle Mechanics: Form, Function, Adaptability (4)

Lecture—4 hours. Prerequisite: basic background in biology, physiology, and engineering; Engineering 35 and 45, Mathematics 21D; Neurobiology, Physiology, and Behavior 101 recommended. Basic structure and function of skeletal muscle examined at the microscopic and macroscopic level. Muscle adaptation in response to aging, disease, injury, exercise, and disuse. Analytic models of muscle function are discussed. Offered in alternate years.—F. Hawkins

231. Musculo-Skeletal System Biomechanics (4)

Lecture—4 hours. Prerequisite: Engineering 102. Mechanics of skeletal muscle and mechanical models of muscle, solution of the inverse dynamics problem, theoretical and experimental methods of kinematic and kinetic analysis, computation of intersegmental load and muscle forces, applications to gait analysis and sports biomechanics. (Same course as Mechanical and Aeronautical Engineering 231.)—S.

232. Skeletal Tissue Mechanics (3)

Lecture—3 hours; laboratory—1 hour. Prerequisite: Engineering 104B. Overview of the mechanical properties of the various tissues in the musculoskeletal system, the relationship of these properties to anatomic and histologic structure, and the changes in these properties caused by aging and disuse. The tissues covered include bone, cartilage and synovial fluid, ligament and tendon. (Same course as Mechanical and Aeronautical Engineering 232.)—S. (S.) Fyhrie

233. Soft Tissue Mechanics (4)

Lecture—4 hours. Presentation of structure and function of musculoskeletal soft tissues: cartilage, tendon, ligament, meniscus, and intervertebral disc. Instruction in engineering principals governing the mechanical behavior of these tissues: viscoelasticity, quasilinear viscoelasticity, and biphasic theory. Offered in alternate years.—W. Christiansen

239. Advanced Finite Elements and Optimization (4)

Lecture—4 hours. Prerequisite: Engineering 180 or Applied Science 115 or Mathematics 128C. Introduction to advanced finite elements and design optimization methods, with application to modeling of complex mechanical, aerospace and biomedical systems. Application of states of the art in finite elements in optimum design of components under realistic loading conditions and constraints. (Same course as Mechanical Engineering 239.) Offered in alternate years.—(W.) Sarigul-Klijn

240. Computational Methods in Nonlinear Mechanics (4)

Lecture—4 hours. Prerequisite: Applied Science Engineering 115 or Mathematics 128B or Engineering 180. Deformation of solids and the motion of fluids treated with state-of-the-art computational methods. Numerical treatment of nonlinear dynamics; classification of coupled problems; applications of finite element methods to mechanical, aeronautical, and biological systems. (Same course as Mechanical and Aeronautical Engineering 240.) Offered in alternate years.—(W.) Sarigul-Klign

241. Introduction to Magnetic Resonance Imaging (3)

Lecture—3 hours. Prerequisite: Physics 9D, Mathematics 22B. Equipment, methods, medical applications of MRI. Lectures review basic, advanced pulse sequences, image reconstruction, display and technology and how these are applied clinically. Lecture complements a more technical course. (course 246 can be taken concurrently.)—F. (F.) 

242. Introduction to Biomedical Imaging (4)

Lecture—4 hours. Prerequisite: Physics 9D and Electrical and Computer Engineering 106 or consent of instructor. Basic physics and engineering principles of image science. Emphasis on ionizing and nonionizing radiation production and interactions with the body and detectors. Major imaging systems: radiography, computed tomography, magnetic resonance, ultrasound, and optical microscopy.—F. (F.) Chaudhari

243. Radiation Detectors for Biomedical Applications (4)

Lecture/discussion—4 hours. Prerequisite: Physics 9D, Mathematics 21D, 22B. Radiation detectors and sensors used for biomedical applications. Emphasis on radiation interactions, detection, measurement and use of radiation sensors for imaging. Operating principles of gas, semiconductor, and scintillation detectors.—W. (W.) Cherry

246. Magnetic Resonance Technology (3)

Lecture—3 hours. Prerequisite: Physics 9D, Mathematics 22B. Course covers MRI technology at an advanced level with emphasis on mathematical descriptions and problem solving. Topics include spin dynamics, signal generation, image reconstruction, pulse sequences, biophysical basis of T1, T2, RF, gradient coil design, signal to noise, image artifacts.—F. 

251. Medical Image Analysis (4)

Lecture—4 hours. Prerequisite: Electrical and Computer Engineering 106. Techniques for assessing the performance of medical imaging systems. Principles of digital image formation and processing. Measurements that summarize diagnostic image quality and the performance of human observers viewing those images. Definition of ideal observer and other mathematical observers that may be used to predict performance from system design features. Offered in alternate years.—W. Qi

252. Computational Methods in Biomedical Imaging (4)

Lecture—4 hours. Prerequisite: course 105 or Statistics 120; course 108 or Electrical and Computer Engineering 150A. Analytic tomographic reconstruction from projections in 2D and 3D; model-based image reconstruction methods; maximum likelihood and Bayesian methods; applications to CT, PET, and SPECT. (Same course as Electrical and Computer Engineering 205.) Offered in alternate years.— W. Qi

255. Biophotonics in Medicine and the Life Sciences (3)

Lecture/discussion—3 hours. Prerequisite: Physics 108 and Biology 101-105; course 202 highly recommended; graduate standing. Introduction to the science and technology of biomedical optics and photonics, with an overview of applications in medicine and the life sciences. Emphasis on research supported by the NSF Center for Biophotonics at UC Davis Medical Center. (Same course as Applied Science 255 and Biophysics 255.) Offered in alternate years.—S. (S.) Chuang

257. Fundamentals of Tissue Optics and Biomedical Applications (5)

Lecture—3 hours; discussion—1 hour; laboratory—3 hours. Fundamentals of optical properties of tissue. Range of optical technologies and their applications to tissue characterization and diagnostics.—S. (S.) Marcu, Wachsmann-Hogiu

262. Cell and Molecular Biophysics for Bioengineers (4)

Lecture—4 hours. Prerequisite: course 284 or equivalent; graduate standing; undergraduate students by consent of instructor. Introduction to fundamental mechanisms governing the structure, function, and assembly of bio-macromolecules. Emphasis is on a quantitative understanding of the nano-to- microscale interactions between and within individual molecules, as well as of their assemblies, in particular membranes. Not open for credit to students who have completed course 162.—W. (W.)  Heinrich

270. Biochemical Systems Theory (4)

Lecture—4 hours. Prerequisite: course 202 concurrently or consent of instructor. Systems biology at the biochemical level. Mathematical and computational methods emphasizing nonlinear representation, dynamics, robustness, and optimization. Case studies of signal-transduction cascades, metabolic networks and regulatory mechanisms. Focus on formulating and answering fundamental questions concerning network function, design, and evolution.—F. Savageau

271. Gene Circuit Theory (4)

Lecture—4 hours. Prerequisite: course 270 or 202 and consent of instructor. Analysis, design, and construction of gene circuits. Modeling strategies, elements of design, and methods for studying variations in design. Case studies involving prokaryotic gene circuits to illustrate natural selection, discovery of design principles, and construction of circuits for engineering objectives.—W. (W.) Savageau

272. Tissue Engineering (3)

Lecture/discussion—3 hours. Prerequisite: Biological Sciences 104 or Molecular and Cellular Biology 121. Based on morphogenetic signals, responding stem cells and extracellular matrix scaffolding. Design and development of tissues for functional restoration of various organs damaged/lost due to cancer, disease and trauma. Fundamentals of morphogenetic signals, responding stem cells and extracellular matrix scaffolding.—W. (W.) Reddi

273. Integrative Tissue Engineering and Technologies (4)

Lecture/discussion—4 hours. Prerequisite: courses 202 and 204 or similar; strongly encourage completion of course 272 although not a prerequisite. Restricted to graduate standing. Engineering principles to direct cell and tissue behavior and formation. Contents include controlled delivery of macromolecules, transport within and around biomaterials, examination of mechanical forces of engineered constructs, and current experimental techniques used in the field.—S. (S.)  Leach

281. Acquisition and Analysis of Biomedical Signals (4)

Lecture—3 hours; laboratory—3 hours. Prerequisite: Engineering 100; Statistics 130A. Restricted to upper division engineering. Basic concepts of digital signal recording and analysis; sampling; empirical modeling; Fourier analysis, random processes, spectral analysis, and correlation applied to biomedical signals.—S. (S.) Srinivasan

284. Mathematical Methods for Biomedical Engineers (4)

Lecture/discussion—4 hours. Prerequisite: Mathematics 22B, Statistics 130A, or consent of instructor; upper division biomedical engineering majors, and graduate students in sciences and engineering; priority given to Biomedical Engineering graduate students. Theoretical applications of linear systems, ordinary and partial differential equations, and probability theory and random processes that describe biological systems and instruments that measure them. Students will be introduced to numerical solution techniques in MATLAB.—W. (W.) Duan

286. Nuclear Imaging in Medicine and Biology (4)

Lecture/discussion—4 hours. Prerequisite: course 243 or consent of instructor. Radioactive decay, interaction of radiation with matter, radionuclide production, radiation detection, digital autoradiography, gamma camera imaging, single photon emission computed tomography, positron emission tomography and applications of these techniques in biology and medicine. Offered in alternate years.—S. Cherry

287. Concepts in Molecular Imaging (4)

Lecture—2 hours; lecture/discussion—2 hours; term paper. Prerequisite: Chemistry 2C, Mathematics 21C, Physics 9D, consent of instructor. Current techniques and tools for molecular imaging. Emphasis on learning to apply principles from the physical sciences to imaging problems in medicine and biology.—S. Sutcliffe

289A. Selected Topics in Biomedical Engineering; Cellular and Molecular Systems Engineering (1-5)

Variable. Prerequisite: consent of instructor. Selected topics in Cellular and Molecular Systems Engineering. May be repeated for credit when topic differs.—F, W, S. (F, W, S.)

289B. Selected Topics in Biomedical Engineering; Biomedical Imaging (1-5)

Variable. Prerequisite: consent of instructor. Selected topics in Biomedical Imaging. May be repeated for credit when topic differs.—F, W, S. (F, W, S.)

289C. Selected Topics in Biomedical Engineering; Computational Bioengineering (1-5)

Variable. Prerequisite: consent of instructor. Selected topics in Computational Bioengineering. May be repeated for credit when topic differs.—F, W, S. (F, W, S.)

289D. Selected Topics in Biomedical Engineering; Cell and Tissue Biomechanics (1-5)

Variable. Prerequisite: consent of instructor. Selected topics in Cell and Tissue Biomechanics. May be repeated for credit when topic differs.—F, W, S. (F, W, S.)

289E. Selected Topics in Biomedical Engineering; Analysis of Human Movement (1-5)

Variable. Prerequisite: consent of instructor. Selected topics in Analysis of Human Movement. May be repeated for credit when topic differs.—F, W, S. (F, W, S.)

290. Seminar (1)

Seminar—1 hour. Seminar in biomedical engineering. (S/U grading only.)

290C. Graduate Research Conference (1)

Discussion—1 hour. Prerequisite: consent of instructor. Individual and/or group conference on problems, progress, and techniques in biomedical engineering research. May be repeated for credit. (S/U grading only.)—F, W, S. (F, W, S.)

298. Directed Group Study (1-5)

Open to graduate students in the Biomedical Engineering Graduate Group, or consent of instructor. Directed group study in Biomedical Engineering. (S/U grading only.)—F, W, S. (F, W, S.) 

299. Research (1-12)

(S/U grading only.)

Professional

396. Teaching Assistant Training Practicum (1-4)

Prerequisite: graduate standing. May be repeated for credit. (S/U grading only.)— F, W, S. (F, W, S.)

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Updated: November 21, 2017 12:17 PM