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Courses in Molecular and Cellular Biology (MCB)

Lower Division

10. Introduction to Human Heredity (4)

Lecture—3 hours; discussion—1 hour. Topics in human heredity and human gene structure and function, including the genetic basis of human development, causes of birth defects, mental retardation, genetic diseases, sexual determination, development, and behavior. GE credit: SciEng | QL, SE, SL.—III. (III.) Engebrecht, Rannala

99. Special Study (1-5)

Independent study—3-15 hours. Prerequisite: consent of instructor. (P/NP grading only.) GE credit: SE.

 Upper Division

120L. Molecular Biology and Biochemistry Laboratory (6)

Laboratory—10 hours; lecture—2 hours; laboratory/discussion—1 hour. Prerequisite: Biological Sciences 103 (may be taken concurrently). Restricted enrollment. Introduction to laboratory methods and procedures employed in studying molecular biology and biochemical processes. Designed for students who need experience in the use of molecular biology and biochemical techniques as research and analytical tools. GE credit: SciEng | QL, SE, SL, VL, WE.—I, II, III. (I, II, III.)

121. Advanced Molecular Biology (3)

Lecture—3 hours. Prerequisite: Biological Sciences 101 and 102 or 105 or Animal Biology 102 (may be taken concurrently, prior completion recommended). Structure, expression, and regulation of eukaryotic genes. Chromosome structure and replication; gene structure, transcription, and RNA processing; protein synthesis and translation control; development, immune system, and oncogenes. Not open for credit to students who have completed Molecular and Cellular Biology 161. GE credit: SciEng | QL, SE, SL.—I, II, III. (I, II, III.) Burgess, Gasser, Harmer, Powers

123. Behavior and Analysis of Enzyme and Receptor Systems (3)

Lecture—3 hours. Prerequisite: Biological Sciences 103. Introduction to the principles of enzyme kinetics and receptor-ligand interactions with emphasis on metabolic regulation and data analysis. Topics include simultaneous equilibria, chemical and steady-state kinetics, allosteric enzymes, mulitreactant systems, enzyme assays, membrane transport and computer-assisted simulations and analyses. GE credit: SciEng | QL, SE.—I, III. (I, III.) Fraser, Wilson

124. Macromolecular Structure and Function (4)

Lecture—4 hours. Prerequisite: Biological Sciences 103, Chemistry 118C. An in-depth investigation into protein and nucleic acid structure and thermodynamics and how these properties influence their biological functions. Key examples of important functional classes of these molecules will be examined. Not open for credit to students who have completed course 122 or Chemistry 108. GE credit: SciEng | SE.—I, II. (I, II.) Baldwin

126. Plant Biochemistry (3)

Lecture—3 hours. Prerequisite: Biological Sciences 103 or 105. The biochemistry of important plant processes and metabolic pathways. Discussion of methods used to understand plant processes, including use of transgenic plants. (Same course as Plant Biology 126.) GE credit: SciEng | SE, SL.—II. (II.) Callis, Tian

138. Undergraduate Seminar in Biochemistry (1)

Seminar—1 hour. Prerequisite: Biological Sciences 103. Discussion of the historical developments of modern biochemistry or current major research problems. May be repeated two times for credit when topic differs. (P/NP grading only.) GE credit: OL, SE.—I, II, III. (I, II, III.) Callis, Gasser, Nunnari

140L. Cell Biology Laboratory (5)

Lecture—2 hours; laboratory—6 hours; discussion—1 hour. Prerequisite: Biological Sciences 104 (may be taken concurrently). Exercises illustrating the principles of cell biology with emphasis on light microscopy. GE credit: SciEng | OL, QL, SE, SL, VL.—II. (II.) Kaplan

142. Advanced Cell Biology: Contractile and Motile Systems (4)

Lecture—3 hours; term paper. Prerequisite: Biological Sciences 102, 104 (may be taken concurrently); Mathematics 16B. Advanced cell biology with emphasis on molecular, biophysical and cellular properties of contractile and motile systems. GE credit: SciEng | SE.

143. Cell and Molecular Biophysics (3)

Lecture—3 hours. Prerequisite: Biological Sciences 101, 102, 103, 104. Physical chemical principles by which molecules form living, moving, reproducing cells. Physical nature of cytoplasm; molecular structure/bonding in macromolecules, macromolecular assemblies and protein machines. Physical techniques and modeling of cytoskeletal polymer-motor dynamics and function during intracellular transport, mitosis and motility. GE credit: SciEng | QL, SE.—III. (III.) Al-Bassam

144. Mechanisms of Cell Division (3)

Lecture—3 hours. Prerequisite: Biological Sciences 101, 102, 104. The molecules and mechanisms that allow eukaryotic cells to coordinate cell growth, DNA replication, segregation of chromosomes and cell division. GE credit: SciEng | SE, WE.—II. (II.) McNally

145. Assembly and Function of Cell Signaling Machinery (3)

Lecture—3 hours. Prerequisite: Biological Sciences 101, 102, 104. Molecular basis of cell signaling, including positioning of cellular machinery, components of various signaling pathways, and downstream effects of signaling on cell adhesion, cell differentiation, and programmed cell death. GE credit: SciEng | SE.—III. (III.) Erickson

148. Undergraduate Seminar in Cell Biology (2)

Seminar—2 hours. Prerequisite: upper division standing in the biological sciences or a related discipline. Student reports on current topics in cell biology with emphasis on integration of concepts, synthesis, and state-of-the-art research approaches. Reviews of literature and reports of undergraduate research may be included. May be repeated for credit. (P/NP grading only.) GE credit: OL, SE.

150. Developmental Biology (4)

Lecture—4 hours. Prerequisite: Biological Sciences 101. Analysis of the mechanistic basis for animal development with a focus on experimental evidence and the relevant fundamental experimental strategies. Fertilization and early development, morphogenesis and patterning, cell differentiation, regulation of cell proliferation and tissue growth. GE credit: SciEng | SE, SL.—III. (III.) Armstrong, Draper, Edwards, Natzle

158. Undergraduate Seminar in Developmental Biology (2)

Seminar—2 hours. Prerequisite: upper division standing in the biological sciences or a related discipline. Student reports on current topics in cell biology with emphasis on integration of concepts, synthesis, and state-of-the-art research approaches. Reviews of literature and reports of undergraduate research may be included. May be repeated for credit. (P/NP grading only.) GE credit: OL, SE.—I, II, III. (I, II, III.)

160L. Principles of Genetics Laboratory (5)

Laboratory—6 hours; lecture—2 hours, discussion/laboratory—1 hour. Prerequisite: Biological Sciences 101. Laboratory work in basic and molecular genetics including gene mapping, isolation and characterization of mutants in eukaryotic model systems, reverse genetics, gel electrophoresis, recombinant DNA techniques, and PCR. Not open for credit to students who have completed Genetics 100L. GE credit: SciEng | QL, SE, VL, WE.—I, II, III. (I, II, III.) Engebrecht, Kiger, Natzle, Rose, Sanders, Sundaresan

162. Human Genetics and Genomics (3)

Lecture—3 hours. Prerequisite: course 121 or equivalent. Human molecular genetic variation, molecular basis of metabolic disorders, chromosome aberrations and consequences, analysis of the human genome, and computational techniques of genetic & genomic analyses. GE credit: SciEng | QL, SE, SL.—I. (I.) Chedin

163. Developmental Genetics (3)

Lecture—3 hours. Prerequisite: course 121. Current aspects of developmental genetics. Historical background and current genetic approaches to the study of development of higher animals. GE credit: SciEng | SE.—II. (II.) Natzle, Rose

164. Advanced Eukaryotic Genetics (3)

Lecture—3 hours. Prerequisite: course 121. Five basic operations of genetic analysis: mutation, segregation, recombination, complementation, and regulation. Emphasis on the theory and practice of isolating and analyzing mutations, as well as understanding mechanisms underlying both Mendelian and epigenetic inheritance. GE credit: SciEng | SE, SL.—III. (III.) Burgess, Engebrecht

178. Undergraduate Seminar in Molecular Genetics (1)

Seminar—1 hour. Prerequisite: upper division standing, completion of Biological Sciences 101, and completion or concurrent enrollment in course 121. Discussion of current topics in molecular genetics to show advanced applications of basic principles and to highlight professional career opportunities. May be repeated one time for credit when topic differs. (P/NP grading only.) GE credit: SciEng | OL, SE.—I, II, III. (I, II, III.) Chedin, Engebrecht, Rodriguez

182. Principles of Genomics (3)

Lecture—3 hours. Prerequisite: Biological Sciences 101. Fundamentals of genomics, including structural genomics, functional genomics, proteomics, and bioinformatics, focusing on the impact of these disciplines on research in the biological sciences. Social impacts of genomic research. GE credit: SciEng | SE.—II. (II.) Burtis, Korf

190C. Undergraduate Research Conference (1)

Discussion—1 hour. Prerequisite: upper division standing and consent of instructor; concurrent enrollment in course 193 or 199. Presentation and discussion of current research by faculty and students. May be repeated for credit. (P/NP grading only.) GE credit: SE.—I, II, III. (I, II, III.)

191. Introduction to Research (1)

Seminar—1 hour. Prerequisite: Biological Sciences 102 (may be taken concurrently) or consent of instructor. Various topics in molecular and cellular biology including biochemistry, genetics, and cell biology will be discussed, along with ways undergraduates can participate in research projects of faculty members. May be repeated for credit. (P/NP grading only.) GE credit: SE.—I, II, III. (I, II, III.)

192. Internship (1-12)

Internship—3-36 hours. Prerequisite: completion of 84 units and consent of instructor. Technical and/or practical experience on and off campus, supervised by a member of the Section of Molecular and Cellular Biology faculty. (P/NP grading only.) GE credit: SE.

193. Advanced Research (3)

Laboratory—6 hours; discussion—1 hour. Prerequisite: upper division standing, completion of an upper division Molecular and Cellular Biology laboratory course and consent of instructor. Research project carried out under the supervision of a faculty sponsor. Discussion and analysis of results and proposed experiments on a weekly basis with faculty sponsor. May include presentation of a seminar to a research group. May be repeated for credit. (P/NP grading only.) GE credit: SE.—I, II, III. (I, II, III.)

194H. Research Honors (3)

Independent study—9 hours. Prerequisite: 6 units of course 193 and/or 199 with faculty director; senior standing; GPA of at least 3.250; consent of Section. Honors project. Continuation of an intensive, individual laboratory research project in biochemistry, genetics, or cell biology culminating with the presentation of the work in a written thesis and in a seminar. (P/NP grading only.) GE credit: OL, SE, WE.

197T. Tutoring in Molecular and Cellular Biology (1-5)

Tutorial—2-6 hours. Prerequisite: upper division standing, completion of course to be tutored, and consent of instructor. Assisting the instructor in one of the section’s regular courses by tutoring individual or small groups of students in a laboratory, in voluntary discussion groups, or other voluntary course activities. May be repeated for credit. (P/NP grading only.) GE credit: SE.—I, II, III. (I, II, III,)

198. Directed Group Study (1-5)

Variable—1-5 hours. Prerequisite: consent of instructor. (P/NP grading only.) GE credit: SE.

199. Special Study for Advanced Undergraduates (1-5)

Independent study—3-15 hours. Prerequisite: consent of instructor. (P/NP grading only.) GE credit: SE.

 Graduate

210. Molecular Genetics and Genomics (3)

Lecture/discussion—3 hours. Prerequisite: Biological Sciences 101 and Molecular & Cellular Biology 121, or equivalent. Pass One restricted to graduate students. Emphasizes molecular genetic and genomic approaches to address fundamental biological questions. Introduces and emphasizes the strengths of prokaryotic and eukaryotic model systems and serves as building block for the BMCDB core courses, which use model systems to develop their themes. May be repeated one time for credit.—I. (I.) Engebrecht

211. Macromolecular Structure and Interactions (3)

Lecture—3 hours. Prerequisite: Biological Sciences 102, or the equivalent, or consent of instructor. Pass One restricted to graduate students. Conceptual and quantitative basis for macromolecular structurefunction relationships. Investigation of the paradigm form follows function. Review of key elements of protein, nucleic acid, and membrane structure. Exploration of specific macromolecular associations by analyzing chemical structure and physical-chemical behavior. No credit for students that have taken course 221A.—I. (I.) Baldwin, Segal, Wilson

212. Cell Biology (3)

Lecture—3 hours. Prerequisite: Biological Sciences 104, or equivalent, or consent of instructor. Pass One restricted to graduate students. Analysis of basic processes governing cell organization, division, and transport. Study of the integration and regulation of cell behavior in response to changes in cellular environment. No credit for students that have taken course 221D.—II. (II.) McNally

213. Developmental Biology (3)

Lecture—3 hours. Prerequisite: undergraduate biology course or consent of instructor. Pass One restricted to graduate students. Fundamental principles in embryonic development that guide application of modern cellular and genetic approaches to understand developmental mechanisms. Emphasis on experimental approaches used to critically address scientific questions.—II. (II.) Erickson

214. Molecular Biology (3)

Lecture—3 hours. Prerequisite: course 211, or equivalent, or consent of instructor. Pass One restricted to graduate students. Investigation of the basic cellular processes in prokaryotes and eukaryotes that govern the central dogma of molecular biology (DNA-RNA-protein). No credit for students that have taken course 221C.—III. (III.) Heyer

215. Graduate Reading Course (2)

Discussion—10 hours. Prerequisite: graduate standing or consent of instructor. Pass One restricted to graduate students. Development of critical reading skills through study of major paradigm advances in specialized fields of biochemistry, molecular, cell, and developmental biology. Emphasis on active learning and student participation. Guided analysis of literature and major advances in field of study. May be repeated two times for credit if topic differs.—III. (III.) Kaplan

220L. Advanced Biochemistry Laboratory Rotations (5)

Laboratory—15 hours. Prerequisite: course 210 and 211 (may be taken concurrently) and 120L or the equivalent. Two five-week assignments in BMCDB research laboratories. Individual research problems with emphasis on methodological/procedural experience, experimental design, proposal writing and oral communication of results. May be repeated two times for credit.—I, II, III. (I, II, III.) Nunnari, Starr

241. Membrane Biology (3)

Lecture—3 hours. Prerequisite: Biological Sciences 102, 103, 104 or consent of instructor. Advanced topics on membrane biochemistry and biophysics. Relationship of the unique properties of biomembranes to their roles in cell biology and physiology. (Same course as Biophysics 241.)—III. (III.) Longo, Voss

248. Seminar in Cell Biology (2)

Seminar—2 hours. Prerequisite: consent of instructor. Discussion of recent literature on the physical and chemical aspects of organization and function of living systems, topics of current interest in ultrastructure and function of cells. Organizational and functional properties of the molecular and cellular levels of biological systems. May be repeated for credit.—I.

251. Molecular Mechanisms in Early Development (3)

Lecture—3 hours. Prerequisite: graduate standing or consent of instructor; introductory background in developmental biology and/or cell biology recommended. Analysis of the early events of development including: germ cells and other stem cells, gametogenesis, meiosis, imprinting, fertilization, genetically-engineered organisms, egg activation and establishment of embryonic polarity with focus on cellular events including gene regulation and cell signaling. Offered in alternate years.—(I.) Draper

255. Molecular Mechanisms in Pattern Formation and Development (3)

Lecture—3 hours. Prerequisite: graduate standing or consent of instructor; introductory background in developmental biology and/or genetics recommended. Genetic and molecular analysis of mechanisms that control animal development after fertilization. Establishment of embryonic axes, cell fate and embryonic pattern; induction, apoptosis, tissue patterning. Critical reading of current literature in C.elegans, Drosophila, and mouse genetic model systems. Offered in alternate years.—III. Natzle, Rose

256. Cell and Molecular Biology of Cancer (2)

Lecture—1 hour; term paper. Prerequisite: course in cell or developmental biology (e.g., course 150, 141, 163, or Biological Sciences 104). Analysis at the cellular and molecular levels of the regulation of normal and neoplastic tissue growth; tumor dissemination; identification and characterization of oncogenic agents; characterization of oncogenes and tumor-suppressor genes.—I. (I.)

257. Cell Proliferation and Cancer Genes (3)

Lecture—1.5 hours; seminar—1.5 hours. Prerequisite: course 221C and 221D or the equivalent. Genetic and molecular alterations underlying the conversion of normal cells to cancers, emphasizing regulatory mechanisms and pathways. Critical reading of the current literature and development of experimental approaches.—I. (I.) Carraway

258. Seminar in Development (2)

Seminar—2 hours. Prerequisite: consent of instructor. Reports and discussion on embryology, morphogenesis, and developmental mechanisms. May be repeated for credit.—II. (II.) Erickson

259. Literature in Developmental Biology (1)

Seminar—1 hour. Prerequisite: consent of instructor. Critical presentation and analysis of recent journal articles in developmental biology. May be repeated for credit. (S/U grading only.)—I, II, III. (I, II, III.) Erickson

263. Biotechnology Fundamentals and Application (2)

Lecture—2 hours. Prerequisite: Biological Sciences 101, 102 and Microbiology 102 or consent of instructor. Must be a graduate student in good standing. Fundamentals of molecular biology and chemical engineering involved in recombinant DNA technology. Topics: principles of rate processes of biological systems, optimization of bioreactors, and issues related to overexpression and production of recombinant molecules. Participation in student-directed team projects.—II. (II.) McDonald, Privalsky, Rodriguez, VanderGheynst

282. Biotechnology Internship (7-12)

Internship—21-36 hours. Prerequisite: graduate standing and consent of instructor. Research at a biotechnology company or interdisciplinary cross-college lab for a minimum of 3 months as part of the Designated Emphasis in Biotechnology Program. (S/U grading only.)—I, II, III. (I, II, III.) Dandekar

290C. Research Conference (1)

Discussion—1 hour. Prerequisite: graduate standing and consent of instructor. Presentations and critical discussions of faculty and graduate student research in molecular and cellular biology including biochemistry, genetics, and cell biology. May be repeated for credit. (S/U grading only.)—I, II, III. (I, II, III.)

291. Current Progress in Molecular and Cellular Biology (1)

Seminar—1 hour. Prerequisite: graduate standing or consent of instructor. Seminars presented by guest lecturers on subject of their own research activities. May be repeated for credit. (S/U grading only.)—I, II, III. (I, II, III.)

294. Current Progress in Biotechnology (1)

Seminar—1 hour. Prerequisite: graduate standing or consent of instructor. Seminars presented by guest lecturers on subjects of their own research activities. May be repeated for credit. (Same course as Chemical Engineering 294.) (S/U grading only.)—I, II, III. (I, II, III.) Kjelstrom, McDonald, Rodriguez

295. Literature in Molecular and Cellular Biology (1)

Seminar—1 hour. Prerequisite: graduate standing and consent of instructor. Critical reading and evaluation of current literature in molecular and cellular biology disciplines. Papers will be presented and discussed in detail. May be repeated for credit. (S/U grading only.)—I, II, III. (I, II, III.) Baldwin, Fisher, Privalsky, Wilson

298. Group Study (1-5)

Variable—1-5 hours. Prerequisite: consent of instructor. (S/U grading only.)

299. Research (1-12)

Independent study—3-36 hours. (S/U grading only.)

 Professional

390. Methods of Teaching (1)

Discussion—1 hour. Prerequisite: graduate standing and consent of instructor. Practical experience in the methods and problems of teaching biochemistry/genetics/cell biology. Includes analysis of texts and supporting material, discussion of teaching techniques, preparing for and conducting discussion and laboratory sections, formulating examinations under supervision of instructor. Participating in the teaching program required for Ph.D. May be repeated for credit. (S/U grading only.)—I, II, III. (I, II, III.)

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Updated: July 11, 2014 9:42 AM