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Courses in Clinical Research (CLH)

Graduate

200. Introduction to Clinical Research (3)

Lecture—2 hours; independent study—3 hours. Prerequisite: one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing. Application and acceptance into the Clinical Research Graduate Group, K30 program or other SOM/CTSC training programs; consent of instructor. Introduction to the CRGG program and overview of major clinical research topics. Overview of basic clinical skills needed to accomplish CRGG mentored research project. (Formerly Medical Science 460CR.) (S/U grading only.)—Su. (Su.) Meyers

201. Strategies for Grant Writing (2)

Lecture—2 hours. Prerequisite: consent of instructor; completed one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing. Application and acceptance into the Clinical Research Graduate Group, K30 program or other SOM/CTSC training program. Practical skills and strategies to create successful grant proposals in NIH style/format. Generating ideas, identifying and accessing research resources, grant components, specific aims, background and significance, preliminary studies, budgets, and bios. Matriculation through UC system, and resubmissions. (Former course Medical Sciences 461CR.) (S/U grading only.)—Su. (Su.) Rutledge

202. Introduction to Clinical Epidemiology and Study Design (3)

Lecture—25 hours; discussion—10 hours. Prerequisite: completed one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing; application and acceptance into the Clinical Research Graduate Group, (K30) program, or other SOM/CTSC training programs. Anatomy and physiology of conducting clinical epidemiologic research. Familiarity with three basic study designs (cross-sectional, case-control, and cohort).Discussion of principles of measurements in clinical epidemiological studies, basic methods for analyzing data, and ethical issues involved in conducting research. (Formerly Medical Sciences 462CR.) (S/U grading only.)—Su. (Su.) McCurdy, Romano

203. Methods in Clinical Research (3)

Lecture—4 hours; discussion—1 hour; independent study—10 hours. Prerequisite: completed one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing; application and acceptance into the Clinical Research Graduate Group, K30 program or other SOM training programs; consent of instructor. Overview of major approaches to clinical research, including health services research techniques, informatics, GCRC, and preclinical methodologies to enhance clinical projects. Overview of UCD clinical research support infrastructure. Methodologies applicable to clinical research and its multi-disciplinary perspective. (S/U grading only.)—Su. (Su.) Schweitzer

204. The Ethics of Research (1)

Lecture—3 hours. Prerequisite: consent of instructor. Priority given to those with acceptance into the Clinical Research Graduate Group, K12, T32 or other SOM/CTSC training program. Acquire information about ethical responsibilities; Explore major questions in ethics; Apply ethical principles, concepts and values; Gain an appreciation of the role of trust in scientific research. Recommend three quarters of CLH204. Must enroll in Fall to continue through Spring. (S/U grading only.)—F, W, S. (F, W, S.) Yarborough

205. Introduction to Medical Statistics (4)

Lecture—3 hours; laboratory—2 hours. Prerequisite: completed one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing; application and acceptance into the Clinical Research Graduate Group, K30 program or other SOM training program; consent of instructor. Biomedical applications of statistical methods in clinical, laboratory, population medicine. Graphical/tabular data presentation, probability, binomial, Poisson, normal, t-, F-, and Chi-square distributions, elementary nonparametric methods, simple linear regression/correlation, life tables. Microcomputer applications of statistical procedures in population medicine. (Formerly Medical Sciences 465CR.) (S/U grading only.)—Su. (Su.) Yang

207. Team Science (1)

Lecture/discussion—1 hour. Prerequisite: participation in CTSC Research Education and Training Programs, or consent of instructor. Restricted to 25 students. Today's scientific challenges necessitate cross-disciplinary engagement and high collaboration levels. This course offers guidance on how best to engage in team science to pursue complex questions, work effectively with team members, and produce high impact research that meets society's needs. (S/U grading only.)—S. (S.) Crumley, Meyers

208. Introduction to Grant Writing, I (2)

Lecture/discussion—2 hours; extensive writing. First in a two-quarter series. Scholars are encouraged to enroll in both classes. The two-course sequence provides training in practical aspects of competitive grant writing. The focus is NIH, but information will apply to other funding agencies. (S/U grading only.)—F. (F.) Chedin, Guo, Ozonoff

209. Introduction to Grant Writing, II (1)

Lecture/discussion—1 hour. Prerequisite: course 208; consent of instructor. Restricted to students who have completed course 208. Second in a two-quarter series. Two-course sequence provides training in practical aspects of competitive grant writing. (S/U grading only.)—W. (W.) Chedin, Guo, Ozonoff

210Y. Principles and Methods of Comparative Effectiveness Research (4)

Web virtual lecture—4 hours; discussion—2 hours; project—6 hours; web electronic discussion. Prerequisite: familiarity with research methodology, and a course in introductory statistics; consent of instructor. Provides an introduction to Comparative Effectiveness Research (CER) and methods for conducting CER. (S/U grading only.)—S. (S.) Fancher, Kravitz, Leigh, Melnikow, Romano, Tancredi

211. Critical Assessment of the Biomedical Literature (1)

Lecture/discussion—1 hour. Prerequisite: consent of instructor. Exposes students to topical issues and controversies in the design of interdisciplinary translational research, with an emphasis on critical assessment of the biomedical and health sciences literature. The course extends students' knowledge of study design through practical application. May be repeated three times for credit. (S/U grading only.)—F, W, S. (F, W, S.) Bold, Franks, Lane, Romano

212. Introduction to Stem Cell Biology (3)

Lecture/discussion—1 hour. Prerequisite: consent of instructor. Introduction to Stem Cell Biology. Each week will focus on different aspects of stem cells, including general concepts, stem cells in lower organisms, embryonic stem cells and cellular reprogramming. Open to graduate students with a fundamental knowledge of cell biology.—F. (F.) Fierro

220. Basics of Stem and Progenitor Cells (1)

Lecture—1 hour. Prerequisite: Molecular, Cellular, and Integrative Physiology 200, 200L; consent of instructor; graduate standing. This is a lecture course designed for graduate students who have experience in cell culture techniques. It is designed to give a broad overview of the field and current cells of interest to the greater research community. (S/U grading only.)—S. (S.) Tarantal

222. Ethical Issues in Stem Cell Biology (1)

Lecture/discussion—1 hour. Prerequisite: consent of instructor; graduate standing. Critical presentation and analysis of recent articles in stem cell biology and small group discussions of the ethical issues surrounding this area of research. (S/U grading only.)—W. (W.) Ikemoto, Rich

230. Congestive Heart Failure, Mechanism of Disease (3)

Lecture/discussion—2 hours; project. Prerequisite: consent of instructor; graduate standing. Underlying mechanisms of cardiomyopathy and heart failure. Presentation of fundamental knowledge of and recent basic research on heart failure. Student team projects: investigation and presentation of a research topic and bench research project to advance research in the same area.—W. (W.) Knowlton

231. Current Techniques in Clinical Research (2)

Lecture—1 hour; clinical activity—3 hours. Prerequisite: consent of instructor and graduate standing; completion of course 250. Current techniques used in clinical research such as electrophysiology, cardiovascular surgery, cardiac catheterization and echocardiography, team science, and patient management. Lectures are presented by experts on each technique, with an emphasis on use in translational research. (S/U grading only.)—F, W, S, Su. (F, W, S, Su.) 

233. Molecular Mechanisms of Disease: Cancer (3)

Lecture/discussion—2 hours; project—3 hours. Prerequisite: consent of instructor. Restricted to students pursuing the designated emphasis in Translational Research; graduate standing. Cutting edge of research on underlying mechanisms of cancer development, progression and prevention--clinical trials/drug development, signaling pathways and molecular mechanisms of cancer development, recent basic research on cancer stem cells, genetics and epigenetic events and animal models used.—W. (W.) Goldkorn

240. Predoctoral Clinical Research Training Program Research Integration (1)

Seminar—0.5 hours; discussion—0.5 hours. Prerequisite: consent of instructor and enrollment in the Predoctoral Clinical Research Training Program in the CTSC, School of Medicine. Alternating sessions: journal club, seminar/discussion, and research integration sessions. May be repeated three times for credit (S/U grading only.)—F, W, S. (F, W, S.) Kenyon

245. Biostatistics for Biomedical Science (4)

Lecture—4 hours. Prerequisite: course 244 or Public Health Sciences 244 or the equivalent; consent of instructor. Analysis of data and design of experiments for laboratory data. (Same course as Public Health Sciences 245.)—W. (W.) Kim

246. Biostatistics for Clinical Research (4)

Lecture—4 hours. Prerequisite: course 245 or Public Health Sciences 245. Emphasizes critical biostatistics for clinical research and targets biomedical audience. Students will develop understanding for basic planning and analysis of clinical studies and learn to develop collaborations with biostatisticians. (Same course as Public Health Sciences 246.) May be repeated for credit. Offered in alternate years.—W. Qi

247. Statistical Analysis for Laboratory Data (4)

Lecture—4 hours. Prerequisite: course 245 or Public Health Sciences 245. Statistical methods for experimental design and analysis of laboratory data including gene expression arrays, RNA-Seq, and mass spec. (Same course as Public Health Sciences 247.)—(S.) Rocke

250. Integrating Medicine Into Basic Science (6)

Lecture—3.75 hours; discussion—6 hours; seminar—2.5 hours; clinical—8 hours. Prerequisite: consent of instructor. Graduate standing; acceptance into HHMI Integrating Medicine into Basic Science program. Four-week summer institute consisting of didactic lectures, reading assignments, group discussions, and clinical rotations to acculturate students to the human medical environment; integrate medical principles, physiology and pathophysiology into basic research; introduce high-impact clinical studies related to medicine and health. (S/U grading only.)—Su. (Su.) Knowlton, Robbins, Stevenson

290A. Hot Topics in Clinical Research (1)

Seminar—1 hour. Prerequisite: graduate standing or consent of instructor. Seminars presented by guest lecturers on subjects of their own research activities. May be repeated for credit. (S/U grading only.)—F, W, S. (F, W, S.) 

290B. Hot Topics in Stem Cell Biology (1)

Seminar—1 hour. Prerequisite: graduate standing. Seminars presented by guest lecturers on subjects of their own research. (S/U grading only.)—F, W, S. (F, W, S.) 

290C. Literature in Translational Research (1)

Discussion—1 hour. Prerequisite: graduate standing and consent of instructor. Critical presentation and analysis of recent journal articles in translational research by students. May be repeated for credit. (S/U grading only.)—F, W, S. (F, W, S.) Knowlton

290D. Literature in Translational Research (1)

Discussion—1 hour. Prerequisite: consent of instructor; graduate standing. Critical presentation and analysis of recent journal articles in translational research by students. May be repeated for credit. (S/U grading only.)—F. (F.) Knowlton

298. Group Study in Clinical Research (1-5)

Prerequisite: consent of instructor. Special topics in Clinical Research appropriate for group study at the graduate level. Restricted to students enrolled in the Mentored Clinical Research Training Program. (S/U grading only.)

299. Clinical Research (1-5)

Prerequisite: consent of instructor. Independent research and special topics in clinical research appropriate for graduate level. Restricted to students enrolled in the Mentored Clinical Research Training Program. (S/U grading only.)

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Updated: March 22, 2017 10:38 AM